Pharmacokinetics Compartment Model L1-402
Unclaimed Principle — open for contribution
This Principle is declared in the catalog but has no reference solver, no pinned dataset, and is not registered on-chain. There is no reward pool. Submitting a cert against this Principle today will record the cert for reproducibility but pay zero PWM.
To claim it as a Bounty #7 contribution: open a PR adding (1) a reference solver, (2) ≥1 dataset pinned to IPFS, (3) updates to the L3 manifest with dataset CIDs. After verifier-agent triple-review, the founders' 3-of-5 multisig signs PWMRegistry.register() and the Principle becomes mineable.
Forward model E
Pharmacokinetics Compartment Model: PK model fitting: estimate clearance CL, volume V, and absorption k_a from plasma concentration-time data. The forward operator produces the measurement through a 3-node primitive DAG (M.ode.pk_compartments…); recovery is posed as a parameter_estimation problem. Difficulty tier delta=3 with effective condition number kappa_eff~50; inter_individual_variability, protein_binding_uncertainty set the accuracy floor at the Omega boundary. See the forward_model field for the closed-form equation.
L-DAG
Well-posedness W
- Existence:
- true
- Uniqueness:
- true
- Stability:
- conditional
- κ:
- 1000
Existence of the recovered PK_parameter_vector is guaranteed within the declared Omega bounds. Uniqueness holds on the measurement-supported subspace; out-of-support modes are controlled by declared priors. Stability is conditionally stable (kappa_eff ~= 50); inter_individual_variability dominates the stability cliff; the remaining mismatch parameters contribute higher-order bias terms. Lognormal sets the irreducible data-fidelity floor.
Solvability C
- Solver class:
- classical [NONMEM_FOCE or Monolix_SAEM or nlmixr]
- Convergence rate q:
- 2
- Complexity:
- O(N_subjects * N_samples * N_params) per NLME fit per iteration